A structure-searchable bioactivity database of toxic chemical substances containing data from in vivo and in vitro studies.
Toxicity Database includes the complete contents of the Registry of Toxic Effects of Chemical Substances database (US Centers for Disease Control and Prevention), the GENE-TOX database (US Environmental Protection Agency) and the Chemical Carcinogenesis Research Information System database (National Cancer Institute).
The structure-searchable bioactivity database of toxic chemical substances contains data from in vivo and in vitro studies of:
- Acute toxicity
- Mutagenicity
- Skin and eye irritation
- Tumorigenicity and carcinogenicity
- Reproductive effects
- Multiple dose effects
Scientists from a variety of disciplines use the database:
- Toxicologists at pharmaceutical and chemical companies
- Drug Safety scientists, both discovery and preclinical development
- Drug metabolism and pharmacokinetics (DMPK) scientists
- Medicinal chemists
- Clinical toxicologists
- Safety officers in pharmaceutical companies – especially in synthesis scale up and production facilities
Toxicity Database can be used in conjunction with Symyx Metabolite Database. A single click enables structure browsing in either database to transfer and view relevant toxicity and biotransformation data.